Little information exists concerning the pharmacological properties, metabolism, and toxicity of flunitrazolam in human beings. Preliminary reviews advise it's higher abuse potential comparable to that of other strong benzodiazepines.

In truth, several of the most strong benzodiazepines belong for the TBZD class, and flunitrazolam is not any exception: research show this benzo is Lively even at sub-milligram doses [1], rendering it notably risky On the subject of overdoses.

Considering that virtually all benzodiazepine compounds share a considerable baseline threat degree that is tied for their Key mechanism of motion, this condition of affairs does not make Considerably perception.

Benzodiazepine overdose is actually a clinical crisis that may produce a coma, lasting brain harm or death if not dealt with promptly and correctly.

Concomitant utilization of CNS depressants contributes to a mutual potentiation of the effects of every drug, and also the final result is an increased chance of overdosing on possibly substance.

Benzodiazepine discontinuation is notoriously difficult; it is potentially existence-threatening for individuals applying often to discontinue use without tapering their dose about a duration of months.

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The half-life of flunitrazolam is 5 to 13 several hours, though its period of outcomes is four to 8. Compared to other benzos, this would make flunitrazolam a short-acting benzodiazepine.

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Sedation - Concerning Power level alterations, this drug has the potential to become very sedating and infrequently leads to an overwhelmingly lethargic point out. At higher concentrations, this brings about users to abruptly truly feel as here Should they be very snooze deprived and possess not slept for times, forcing them to sit down and generally feel as When they are continuously to the verge of passing out instead of engaging in Bodily things to do.

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There remains to be no circumstance of flunitrazolam poisoning explained during the literature and the potential risk of lacking it throughout standard screening is large, irrespective of the analytical approach employed.